From probiotics to therapeutics: another step forward?

From probiotics to therapeutics: another step forward?

Preclinical studies with probiotics continue to unravel mechanisms of cytoprotection and suggest that approaches utilizing microbial products as therapeutics in acute and chronic gastrointestinal disorders could be effective. However, clinical trials using these bacteria have thus far been inconsistent. In this issue of the JCI, Yan et al. describe a novel mechanism of cytoprotection by p40, a ...

Another Step Forward in CT Angiography.

Coronary angiography has been the “holy grail” of noninvasive cardiovascular imaging. From the first attempts to image coronary arteries by noninvasive imaging (1,2), the complex motion of this arterial system in humans has been recognized as the most important challenge to be met. The small luminal diameter of the coronary vessel and its capricious trajectory in 3-dimensional (3D) space repres...

Closing the Loop: Another Step Forward

To achieve normoglycemia in people with diabetes, the complex hormonal and neuronal influences that regulate glucose homeostasis must be understood and addressed. In addition to insulin deficiency, abnormalities include dysregulation in the secretion and/or action of glucagon, incretins, and other counterregulatory hormones. Efforts to restore normalmetabolism in diabetes with insulin therapy a...

HPV Vaccination in Males: Another Step Forward

Article history: Received 22 September 2015 Accepted 22 September 2015 Available online 25 September 2015 time of infection clearance of HPV is usually short, even if the consensus among researchers is lacking about this issue (Giuliano et al., 2011). Giuliano reported that the mean time-to infection clearance (i.e., the time necessary to determine a complete regression in at least 50% of infec...

One step forward